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Facts about hypogonadism

The field of hormone replacement is one of the most successful in medicine. It doesn't make sense then that hormone replacement clinical trials for the treatment of hypogonadism would fail.

The failure of these clinical trials is not the failure of HRT or hormone replacement. Rather it is the failure of the medication used. The medications used did not replacement all of the hormones that the gonads produce. All of the hormones together from the gonads are what keep a person healthy. Not replacing all of them will not restore health. To restore health all of the hormones must be replaced.

Since all of the hormones are not replaced the medications are more accurately called non-HRT or not complete or incomplete hormone replacement.


If you don't find an answer in our FAQ section please email us and we will answer it and post it here. Please send questions to questions@diamondrf.org

What are the gonads?

In women the gonads are called ovaries and in men the gonads are called testicles.

Which hormones are produced by the ovary and the testicle?

The ovary and testicle produce identical hormones, estradiol, progesterone, dhea and testosterone just in differing amounts.

When is the level of estradiol the same in men and women?

A healthy man's estradiol level has a steady level of about 20-30 pg/ml. A woman's estradiol level drops to about 30 pg/ml for about a day once a month.

Estradiol is the major circulating estrogen in both women and men

When is a man's estradiol level higher than a woman's?

A man's estradiol will generally increase as he ages unless something is done about it. By the age of 50-70 years a man's estradiol level is about 5-10 times higher than a woman's of a similar age.

Between the ages of 50-70 years a man's estradiol will be approximately 30-50 pg/ml.

Between the ages of 50-70 years a woman's estradiol will be approximately 1-10 pg/ml

I thought andropause and menopause were not illnesses

The medical name for andropause and menopause is hypogonadism.

In women hypogonadism is usually called peri-menopause. Advanced or profound hypogonadism is usually called menopause.

In men this illness is just called hypogonadism. When this illness has advanced in men it is called profound or advanced hypogonadism.

Hypogonadism in women and men is an illness and can be treated successfully with the right medications.

Does hypogonadism have the same symptoms for women and men?

Yes, the symptoms are the same. They are the same because the gonadal hormones, progesterone, testosterone, estradiol and dhea have the same function whether they are in a man's or a woman's body.

I thought hypogonadism only happened to men

Hypogonadism happens to all people, women and men, over the age of 30 years.

I thought it was normal to leave hypogonadism untreated in women.

Culturally, we have been taught to ignore hypogonadism in women and to minimize hypogonadism in men. From a medical standpoint hypogonadism is a treatable illness in women and men.

Isn't menopause natural?

It is natural for the ovaries to use the eggs contained within it to produce hormones to keep a woman healthy.

I thought HRT clinical trials proved that HRT is bad for women

The clinical trials that have been done on women proved that non-HRT is bad for women. Not one of these trials actually used HRT. Absolutely no hormone testing was done before, during or after the start of these 'HRT' clinical trials.

Why wouldn't hormone testing be done in a clinical trial that advertised that it used HRT?

Because hormone replacement was not the goal of the clinical trial. If the clinical trial actually used HRT then hormone testing would have been done.

What would be the goal of an HRT trial that didn't make sure replacement levels of hormones were used?

Diamond Research Foundation has asked The National Institutes of Health it has refused to answer this question.

Why did the National Institutes of Health stop calling the hormone drug, Premarin, used in the Women's Health Initiative and the PEPI clinical trials HRT and now calls it HT or hormone therapy?

Because no hormone replacement can be achieved with this drug.

Should your doctor provide treatment for hypogonadism?

Yes. However, your doctor may be as confused as you because of the non-HRT trials being called HRT trials. You can explain to your doctor that the results of non-HRT trials prove non-HRT is unhealthy.

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